Essential Tremor Associated With Pathologic Changes in the Cerebellum

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Essential tremor associated with pathologic changes in the cerebellum.

BACKGROUND Although essential tremor (ET) is one of the most common neurologic disorders, there have been few postmortem studies. We recently reported postmortem changes (torpedoes and Bergmann gliosis) in the cerebellar cortex in a few ET cases. OBJECTIVE To describe more extensive postmortem changes in the cerebellum in another ET case. DESIGN Case report. RESULTS A 90-year-old woman ha...

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"Hairy baskets" associated with degenerative Purkinje cell changes in essential tremor.

Essential tremor (ET) is one of the most common neurologic diseases. Increased numbers of torpedoes and Purkinje cell (PC) loss have been documented in the brains of patients with ET. We recently observed a dense and tangled appearance ("hairiness") of the basket cell axonal plexuses that surround PC soma in Bielschowsky preparations of cerebellar cortex in ET brains. Here, we assessed basket c...

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SLC1A2 Variant Is Associated with Essential Tremor in Taiwanese Population

Essential tremor (ET), which is one of the most common movement disorders, may lead to severe interference in quality of life. The first genome-wide association study (GWAS) has identified an association of the LINGO1 variant (rs9652490) with ET in Americans and Europeans. Recently, a second GWAS that was performed in a European population has discovered a new variant (rs3794087) of the main gl...

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Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum.

Structural changes in Purkinje cells have been identified in the essential tremor cerebellum, although the mechanisms that underlie these changes remain poorly understood. Climbing fibres provide one of the major excitatory inputs to Purkinje cells, and climbing fibre-Purkinje cell connections are essential for normal cerebellar-mediated motor control. The distribution of climbing fibre-Purkinj...

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ژورنال

عنوان ژورنال: Archives of Neurology

سال: 2006

ISSN: 0003-9942

DOI: 10.1001/archneur.63.8.1189